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Understanding the impact of renal or hepatic impairment on the pharmacokinetic properties of cagrilintide is crucial for managing overweight and obesity in individuals with these conditions, particularly as chronic kidney disease and liver disease including metabolic dysfunction-associated steatotic liver disease are common comorbidities of obesity

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[34] revealed that the ectopic expression of IGF-1 in mouse skin increased the FoxP3-positive Treg cells which secreted an increased level of the IL-10 cytokine